Barcelona started the new year with a slim win against Huesca on Sunday night.
Messi, who missed the side’s last game of 2020 due to injury, started and assisted the only goal of the match.
Midfielder Frenkie De Jong made a brilliant run into the box to tap home Messi’s delightful cross.
The game was Messi’s 750th match for Barcelona and 500th in La Liga.
The result means Barcelona move up to fifth place in the Spanish top flight but they remain 10 points adrift of leaders Atletico Madrid, who have played one game fewer.